@article {wu_joint_2010,
	title = {Joint Inference on HIV Viral Dynamics and Immune Suppression in Presence of Measurement Errors},
	journal = {Biometrics},
	volume = {66},
	number = {2},
	year = {2010},
	month = {jun},
	pages = {327{\textendash}335},
	abstract = {Summary:  In an attempt to provide a tool to assess antiretroviral therapy and to monitor disease progression, this article studies association of human immunodeficiency virus (HIV) viral suppression and immune restoration. The data from a recent acquired immune deficiency syndrome (AIDS) study are used for illustration. We jointly model HIV viral dynamics and time to decrease in CD4/CD8 ratio in the presence of CD4 process with measurement errors, and estimate the model parameters simultaneously via a method based on a Laplace approximation and the commonly used Monte Carlo EM algorithm. The approaches and many of the points presented apply generally.},
	keywords = {Laplace approximation, Longitudinal data, Mixed-effects, Nonlinear models, Time-to-event},
	issn = {1541-0420},
	doi = {10.1111/j.1541-0420.2009.01308.x},
	url = {http://onlinelibrary.wiley.com/doi/10.1111/j.1541-0420.2009.01308.x/abstract},
	author = {Wu, L. and Liu, W. and Hu, X. J.}
}
