@article { ISI:000273783100027,
	title = {The Genetic Landscape of a Cell},
	journal = {SCIENCE},
	volume = {327},
	number = {5964},
	year = {2010},
	month = {JAN 22},
	pages = {425-431},
	publisher = {AMER ASSOC ADVANCEMENT SCIENCE},
	type = {Article},
	address = {1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA},
	abstract = {A genome-scale genetic interaction map was constructed by examining 5.4 million gene-gene pairs for synthetic genetic interactions, generating quantitative genetic interaction profiles for similar to 75\% of all genes in the budding yeast, Saccharomyces cerevisiae. A network based on genetic interaction profiles reveals a functional map of the cell in which genes of similar biological processes cluster together in coherent subsets, and highly correlated profiles delineate specific pathways to define gene function. The global network identifies functional cross-connections between all bioprocesses, mapping a cellular wiring diagram of pleiotropy. Genetic interaction degree correlated with a number of different gene attributes, which may be informative about genetic network hubs in other organisms. We also demonstrate that extensive and unbiased mapping of the genetic landscape provides a key for interpretation of chemical-genetic interactions and drug target identification.},
	issn = {0036-8075},
	doi = {10.1126/science.1180823},
	author = {Costanzo, Michael and Baryshnikova, Anastasia and Bellay, Jeremy and Kim, Yungil and Spear, Eric D. and Sevier, Carolyn S. and Ding, Huiming and Koh, Judice L. Y. and Toufighi, Kiana and Mostafavi, Sara and Prinz, Jeany and Onge, Robert P. St. and VanderSluis, Benjamin and Makhnevych, Taras and Vizeacoumar, Franco J. and Alizadeh, Solmaz and Bahr, Sondra and Brost, Renee L. and Chen, Yiqun and Cokol, Murat and Deshpande, Raamesh and Li, Zhijian and Lin, Zhen-Yuan and Liang, Wendy and Marback, Michaela and Paw, Jadine and Luis, Bryan-Joseph San and Shuteriqi, Ermira and Tong, Amy Hin Yan and van Dyk, Nydia and Wallace, Iain M. and Whitney, Joseph A. and Weirauch, Matthew T. and Zhong, Guoqing and Zhu, Hongwei and Houry, Walid A. and Brudno, Michael and Ragibizadeh, Sasan and Papp, Balazs and Pal, Csaba and Roth, Frederick P. and Giaever, Guri and Nislow, Corey and Troyanskaya, Olga G. and Bussey, Howard and Bader, Gary D. and Gingras, Anne-Claude and Morris, Quaid D. and Kim, Philip M. and Kaiser, Chris A. and Myers, Chad L. and Andrews, Brenda J. and Boone, Charles}
}
