@article { ISI:000335157700044,
	title = {Polarization of the Effects of Autoimmune and Neurodegenerative Risk Alleles in Leukocytes},
	journal = {SCIENCE},
	volume = {344},
	number = {6183},
	year = {2014},
	month = {MAY 2},
	pages = {519-523},
	publisher = {AMER ASSOC ADVANCEMENT SCIENCE},
	type = {Article},
	address = {1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA},
	abstract = {To extend our understanding of the genetic basis of human immune function and dysfunction, we performed an expression quantitative trait locus (eQTL) study of purified CD4(+) T cells and monocytes, representing adaptive and innate immunity, in a multi-ethnic cohort of 461 healthy individuals. Context-specific cis- and trans-eQTLs were identified, and cross-population mapping allowed, in some cases, putative functional assignment of candidate causal regulatory variants for disease-associated loci. We note an over-representation of T cell-specific eQTLs among susceptibility alleles for autoimmune diseases and of monocyte-specific eQTLs among Alzheimer{\textquoteright}s and Parkinson{\textquoteright}s disease variants. This polarization implicates specific immune cell types in these diseases and points to the need to identify the cell-autonomous effects of disease susceptibility variants.},
	issn = {0036-8075},
	doi = {10.1126/science.1249547},
	author = {Raj, Towfique and Rothamel, Katie and Mostafavi, Sara and Ye, Chun and Lee, Mark N. and Replogle, Joseph M. and Feng, Ting and Lee, Michelle and Asinovski, Natasha and Frohlich, Irene and Imboywa, Selina and Von Korff, Alina and Okada, Yukinori and Patsopoulos, Nikolaos A. and Davis, Scott and McCabe, Cristin and Paik, Hyun-il and Srivastava, Gyan P. and Raychaudhuri, Soumya and Hafler, David A. and Koller, Daphne and Regev, Aviv and Hacohen, Nir and Mathis, Diane and Benoist, Christophe and Stranger, Barbara E. and De Jager, Philip L.}
}
