@article { ISI:000354045700036,
	title = {The Genotype-Tissue Expression (GTEx) pilot analysis: Multitissue gene regulation in humans},
	journal = {SCIENCE},
	volume = {348},
	number = {6235},
	year = {2015},
	month = {MAY 8},
	pages = {648-660},
	publisher = {AMER ASSOC ADVANCEMENT SCIENCE},
	type = {Article},
	address = {1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA},
	abstract = {Understanding the functional consequences of genetic variation, and how it affects complex human disease and quantitative traits, remains a critical challenge for biomedicine. We present an analysis of RNA sequencing data from 1641 samples across 43 tissues from 175 individuals, generated as part of the pilot phase of the Genotype-Tissue Expression (GTEx) project. We describe the landscape of gene expression across tissues, catalog thousands of tissue-specific and shared regulatory expression quantitative trait loci (eQTL) variants, describe complex network relationships, and identify signals from genome-wide association studies explained by eQTLs. These findings provide a systematic understanding of the cellular and biological consequences of human genetic variation and of the heterogeneity of such effects among a diverse set of human tissues.},
	issn = {0036-8075},
	doi = {10.1126/science.1262110},
	author = {Ardlie, Kristin G. and DeLuca, David S. and Segre, Ayellet V. and Sullivan, Timothy J. and Young, Taylor R. and Gelfand, Ellen T. and Trowbridge, Casandra A. and Maller, Julian B. and Tukiainen, Taru and Lek, Monkol and Ward, Lucas D. and Kheradpour, Pouya and Iriarte, Benjamin and Meng, Yan and Palmer, Cameron D. and Esko, Tonu and Winckler, Wendy and Hirschhorn, Joel N. and Kellis, Manolis and MacArthur, Daniel G. and Getz, Gad and Shabalin, Andrey A. and Li, Gen and Zhou, Yi-Hui and Nobel, Andrew B. and Rusyn, Ivan and Wright, Fred A. and Lappalainen, Tuuli and Ferreira, Pedro G. and Ongen, Halit and Rivas, Manuel A. and Battle, Alexis and Mostafavi, Sara and Monlong, Jean and Sammeth, Michael and Mele, Marta and Reverter, Ferran and Goldmann, Jakob M. and Koller, Daphne and Guigo, Roderic and McCarthy, Mark I. and Dermitzakis, Emmanouil T. and Gamazon, Eric R. and Im, Hae Kyung and Konkashbaev, Anuar and Nicolae, Dan L. and Cox, Nancy J. and Flutre, Timothee and Wen, Xiaoquan and Stephens, Matthew and Pritchard, Jonathan K. and Tu, Zhidong and Zhang, Bin and Huang, Tao and Long, Quan and Lin, Luan and Yang, Jialiang and Zhu, Jun and Liu, Jun and Brown, Amanda and Mestichelli, Bernadette and Tidwell, Denee and Lo, Edmund and Salvatore, Michael and Shad, Saboor and Thomas, Jeffrey A. and Lonsdale, John T. and Moser, Michael T. and Gillard, Bryan M. and Karasik, Ellen and Ramsey, Kimberly and Choi, Christopher and Foster, Barbara A. and Syron, John and Fleming, Johnell and Magazine, Harold and Hasz, Rick and Walters, Gary D. and Bridge, Jason P. and Miklos, Mark and Sullivan, Susan and Barker, Laura K. and Traino, Heather M. and Mosavel, Maghboeba and Siminoff, Laura A. and Valley, Dana R. and Rohrer, Daniel C. and Jewell, Scott D. and Branton, Philip A. and Sobin, Leslie H. and Barcus, Mary and Qi, Liqun and McLean, Jeffrey and Hariharan, Pushpa and Um, Ki Sung and Wu, Shenpei and Tabor, David and Shive, Charles and Smith, Anna M. and Buia, Stephen A. and Undale, Anita H. and Robinson, Karna L. and Roche, Nancy and Valentino, Kimberly M. and Britton, Angela and Burges, Robin and Bradbury, Debra and Hambright, Kenneth W. and Seleski, John and Korzeniewski, Greg E. and Erickson, Kenyon and Marcus, Yvonne and Tejada, Jorge and Taherian, Mehran and Lu, Chunrong and Basile, Margaret and Mash, Deborah C. and Volpi, Simona and Struewing, Jeffery P. and Temple, Gary F. and Boyer, Joy and Colantuoni, Deborah and Little, Roger and Koester, Susan and Carithers, Latarsha J. and Moore, Helen M. and Guan, Ping and Compton, Carolyn and Sawyer, Sherilyn J. and Demchok, Joanne P. and Vaught, Jimmie B. and Rabiner, Chana A. and Lockhart, Nicole C. and Ardlie, Kristin G. and Getz, Gad and Wright, Fred A. and Kellis, Manolis and Volpi, Simona and Dermitzakis, Emmanouil T. and GTEx Consortium}
}
